HCID 22902236, Verbindung → HCID 22902199, Verbindung
Reaktionsgleichung
COC([NH:5][C:6]12[CH2:14][N:13](C(OC)=O)[CH2:12][CH:11]1[CH:10]=[CH:9][CH:8]=[CH:7]2)=O>O>[CH2:12]1[CH:11]2[C:6]([NH2:5])([CH:7]=[CH:8][CH:9]=[CH:10]2)[CH2:14][NH:13]1Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
20 g of crude methyl 1-methoxycarbonylamino-8-azabicyclo[4.3.0]nona-2,4-diene-8-carboxylate are heated with 75 g (0.235 mol) of Ba(OH)2.8 H2O in 250 ml of water overnight under reflux. The BaCO3 is filtered off with suction, the filtrate is concentrated and the salt residues are boiled three times with 1,4-dioxane. The dioxane solutions are concentrated and the residue is distilled. Yield: 5 g (43.9% of theory based on Step D), boiling point: 65° C./0.2 mbar.
Aufarbeitung
- filtrationThe BaCO3 is filtered off with suction
- concentrationthe filtrate is concentrated
- concentrationThe dioxane solutions are concentrated
- distillationthe residue is distilled
Quellen und Nachweise
- ORD-Eintrag
- ord-8bf60291ce6f49f58192a3707e6d10fc
- Quelldatensatz
- uspto-grants-1997_10
- Patentnummer
- US05679689
Notizen zur Reaktion
Wird geladen…