HCID 18184366, Verbindung → HCID 18184387, Verbindung

HRID 1489580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1489580
[N+:1]([C:4]1[CH:12]=[C:11]([N+:13]([O-])=O)[C:10]([OH:16])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7])([O-])=O>CO.CCOC(C)=O.[Pd]>[NH2:1][C:4]1[CH:12]=[C:11]([NH2:13])[C:10]([OH:16])=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7]

Komponenten

4

Edukt 1

HCID 18184366HCID 18184366, Verbindung

Produkt 1

HCID 18184387HCID 18184387, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 21584119Ethylacetate methanolLösungsmittel

Versuchsvorschrift

A solution of 2,4-dinitro-5-hydroxybenzamide (4.00 g, 0.018 mmol) in MeOH/EtOAc (1:1, 50 mL) is hydrogenated over 5% Pd/C at 60 psi for 3 h to give 2,4-diamino-5-hydroxybenzamide, which is used directly. Formic acid (50 mL) is added and the solution is heated under reflux for 48 h. then the volatiles are removed under reduced pressure. The residue is triturated with EtOAc to give crude 4-oxo-3H-oxazolo[5,4-g]quinazoline(3.27 g, 97%) as a tan powder which is used directly.

Quellen und Nachweise

ORD-Eintrag
ord-f65a16e84abc4c61bd982f254ae3bc70
Quelldatensatz
uspto-grants-1997_10
Patentnummer
US05679683

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