2-Methoxythiophene → 2-(5-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Reaktionsgleichung
COc1cccs1>B1Oc2ccccc2O1.C1=CC2C=CC1C2.CC(C)(O)C(C)(C)O.CCN(CC)CC.Cc1ccccc1.Fc1c(F)c(F)c(B(c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2F)c(F)c1F>COc1ccc(B2OC(C)(C)C(C)(C)O2)s1Komponenten
8
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 6
Reaktionsbedingungen
- Temperatur
- 25 °C
Versuchsvorschrift
Prepared from 2-methoxythiophene (4j, 114.2 mg, 1.00 mmol, 1.00 equiv), catBH (240 mg, 2.00 mmol, 2.00 equiv), N,N,4-trimethylaniline (1f, 13.5 mg, 0.10 mmol, 0.10 equiv), norbornene (94.0 mg, 1.00 mmol, 1.00 equiv), and B(C6F5)3 (51.2 mg, 0.10 mmol, 0.10 equiv) according to GP 3. The title compound was purified by flash column chromatography using cyclohexane/EtOAc/Et3N (30/1/1) as eluent to afford 6j[S5] (96.8 mg, 40%) as a colorless liquid.
Quellen und Nachweise
- ORD-Eintrag
- ord-9284ce38474e4c6197f167142a799d26
- Quelldatensatz
- Borylation dataset from Roche
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