Ethanol → 2-Methylsulphonyl-3-phenylsulphenylbenzoic acid

HRID 1491579Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1491579
[CH3:1][S:2]([C:5]1[C:14]([S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8])(=[O:4])=[O:3].C(O)C.[OH-].[Na+]>O>[CH3:1][S:2]([C:5]1[C:14]([S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8])(=[O:4])=[O:3]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 18953302Methyl 2-methylsulphonyl-3-phenylsulphenylbenzoate

Produkt 1

HCID 189533112-Methylsulphonyl-3-phenylsulphenylbenzoic acidAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of methyl 2 -methylsulphonyl-3-phenylsulphenylbenzoate (8.3 g), ethanol (50 ml) and 2N sodium hydroxide (25 ml) was heated at reflux for one hour and then added to water. The inorganic phase was washed with ethyl acetate, acidified with concentrated hydrochloric acid and extracted with ethyl acetate. This organic phase was dried over sodium sulphate, filtered and evaporated giving 7.9 g of 2-methylsulphonyl-3-phenylsulphenylbenzoic acid as a white solid, m.p. 185.4°-186.0° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for one hour
  3. washThe inorganic phase was washed with ethyl acetate
  4. extractionextracted with ethyl acetate
  5. dry with materialThis organic phase was dried over sodium sulphate
  6. filtrationfiltered
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-2bea5c5b7e5f4d37890d6d902c04f47e
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05371064

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