N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea → 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone

HRID 1491782Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1491782
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[F:17])=[O:8])C>CO.O.Cl>[F:17][C:11]1[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:10]=1[N:9]1[CH:4]=[CH:5][NH:6][C:7]1=[O:8]

Komponenten

5

Edukt 1

HCID 19065111N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea

Produkt 1

HCID 190650921-(2,4-difluorophenyl)-2(1H,3H)-imidazoloneAusbeute 89,4 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

This urea (37.5 g) was dissolved in a mixture of 560 mL of methanol and 280 ml of water, and 300 ml of 0.48M hydrochloric acid was added thereto and the resulting mixture was stirred for three days at room temperature. The reaction solution was concentrated under reduced pressure. The crystals thus separated out were washed with a mixture of water and methanol (5:1) to give 22.8 g of 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone as a colorless powder.

Aufarbeitung

  1. additionwas added
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customThe crystals thus separated out
  4. washwere washed with a mixture of water and methanol (5:1)

Quellen und Nachweise

ORD-Eintrag
ord-7d9426dd9d8245df809e2f9ba752fa24
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05371101

Notizen zur Reaktion

Wird geladen…