Acetyl chloride → Acetamide, N-(2,6-dichlorophenyl)-

HRID 1493496Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1493496
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:3]=1[NH2:4].[C:10](Cl)(=[O:12])[CH3:11]>C(O)(=O)C>[CH3:11][C:10]([NH:4][C:3]1[C:2]([Cl:1])=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:9])=[O:12]

Komponenten

4

Edukt 2

HCID 6367Acetyl chlorideHCID 118462,6-Dichloroaniline

Produkt 1

HCID 28698Acetamide, N-(2,6-dichlorophenyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mechanically stirred solution of 2,6-dichloroaniline (76 g, 0.047 mol) in 60 mL of glacial acetic acid is added dropwise acetyl chloride (36 mL, 0.5 mol). After the addition is complete, the reaction mixture is heated at 90° C. for 20 minutes. The solution is poured into ice water (500 mL), forming a white precipitate. The solids are filtered, washed with water and dried to give the product (91.8 g, 96%, white solid, m.p. 179°-180° C., lit. m.p. 180°-181° C. from glacial acetic acid).

Aufarbeitung

  1. additionAfter the addition
  2. customforming a white precipitate
  3. filtrationThe solids are filtered
  4. washwashed with water
  5. customdried
  6. customto give the product (91.8 g, 96%, white solid, m.p. 179°-180° C., lit. m.p. 180°-181° C. from glacial acetic acid)

Quellen und Nachweise

ORD-Eintrag
ord-98ed9fce6a324ceab8053d2b51e9f9a4
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05021576

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