Hydrochloric Acid → 3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride

HRID 1493581

Reaktionsgleichung

Reaktionsgleichung von HRID 1493581
[C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2].[ClH:9].[CH3:10][NH:11][CH3:12].[CH2:13]=O.Cl>C(O)C.CC(C)=O>[ClH:9].[CH3:10][N:11]([CH3:13])[CH2:12][CH2:2][C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)=[O:3]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 69202-AcetylthiopheneHCID 10473Dimethylamine, hydrochloride

Produkt 1

HCID 28768913-(Dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochlorideAusbeute 155,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A mixture of 2-acetylthiophene (63.1 g, 0.5 mol), dimethylamine hydrochloride (53.0 g, 0.65 mol), paraformaldehyde (19.8 g, 0.22 mol), and 12N hydrochloric acid (1 ml) in ethanol (80 ml) was refluxed for one and one-half hours. The solution was diluted with ethanol (100 ml) and acetone (500 ml). The solution was chilled overnight and the resulting solid was collected by filtration to yield 75.0 g (73%) of 3-dimethylamino-1-(2-thienyl)-1-propanone hydrochloride as a colorless crystalline solid. mp =182° C.-184° C.

Aufarbeitung

  1. temperaturewas refluxed for one and one-half hours
  2. temperatureThe solution was chilled overnight
  3. filtrationthe resulting solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-84ab1556f112429aa3c3af0c90e4d4a4
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05023269

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