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Barium Carbonate → HCID 178476214, Verbindung

HRID 1493669
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1493669
C(=O)([O-])[O-].[Ba+2].[CH3:6][CH2:7][CH2:8][CH2:9][CH:10]1[C:45](=[O:46])[O:44][CH:43]([CH:47]([CH:49]([OH:57])[CH2:50][CH2:51][CH2:52][NH:53][C:54]([NH2:56])=[NH:55])[CH3:48])[CH:42]([CH3:58])[CH:41]=[C:40]([CH3:59])[CH2:39][CH2:38][CH2:37][CH2:36][CH:35]([OH:60])[CH2:34][CH:33]([OH:61])[CH2:32][CH:31]([OH:62])[CH2:30][CH:29]([OH:63])[CH2:28][CH:27]([OH:64])[CH:26]([O:65][C@H:66]2[O:70][C@H:69]([CH2:71][OH:72])[C@@H:68]([OH:73])[C@@H:67]2[OH:74])[CH:25]=[C:24]([CH3:75])[CH:23]([OH:76])[CH2:22][CH2:21][CH2:20][CH:19]([OH:77])[CH2:18][CH2:17][CH2:16][CH:15]([OH:78])[CH2:14][CH2:13][CH:12]([CH3:79])[CH:11]1[OH:80].S([O-])([O-])(=O)=O>C(O)(=O)C.CO>[CH3:6][CH2:7][CH2:8][CH2:9][CH:10]1[C:45](=[O:46])[O:44][CH:43]([CH:47]([CH:49]([OH:57])[CH2:50][CH2:51][CH2:52][NH:53][C:54]([NH2:56])=[NH:55])[CH3:48])[CH:42]([CH3:58])[CH:41]=[C:40]([CH3:59])[CH2:39][CH2:38][CH2:37][CH2:36][CH:35]([OH:60])[CH2:34][CH:33]([OH:61])[CH2:32][CH:31]([OH:62])[CH2:30][CH:29]([OH:63])[CH2:28][CH:27]([OH:64])[CH:26]([O:65][C@H:66]2[O:70][C@H:69]([CH2:71][OH:72])[C@@H:68]([OH:73])[C@@H:67]2[OH:74])[CH:25]=[C:24]([CH3:75])[CH:23]([OH:76])[CH2:22][CH2:21][CH2:20][CH:19]([OH:77])[CH2:18][CH2:17][CH2:16][CH:15]([OH:78])[CH2:14][CH2:13][CH:12]([CH3:79])[CH:11]1[OH:80].[C:45]([O-:46])(=[O:44])[CH3:10]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 2

HCID 10563Barium CarbonateHCID 178441404HCID 178441404, Verbindung

Produkt 1

HCID 178476214HCID 178476214, VerbindungAusbeute 186,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

0.88 g (4.459 millimoles) of anhydrous barium carbonate is stirred in 10 ml of acetic acid at 100° C. until the solid goes completely into solution. The solvent is removed in vacuo. The residue is dissolved in 20 ml of methanol, and the solution is poured into a suspension of 10 g (8.87 millimoles) of primycin sulfate in 600 ml of methanol. The suspension is heated to boiling for 10 minutes under constant stirring. The precipitated barium sulfate is filtered off through a Celite filtration auxiliary agent and the filtrate is evaporated in vacuo. The residue is treated with 50 ml of a 2:1 mixture of acetone and water and filtered. The solid is dried under an infra lamp. Thus 9.4 g of primycin acetate are obtained, yield 91.43%. Mp.: 186°-188° C., /α/D25 =+30°.

Aufarbeitung

  1. customThe solvent is removed in vacuo
  2. dissolutionThe residue is dissolved in 20 ml of methanol
  3. temperatureThe suspension is heated
  4. filtrationThe precipitated barium sulfate is filtered off through a Celite filtration auxiliary agent
  5. customthe filtrate is evaporated in vacuo
  6. additionThe residue is treated with 50 ml of a 2:1 mixture of acetone and water
  7. filtrationfiltered
  8. customThe solid is dried under an infra lamp

Quellen und Nachweise

ORD-Eintrag
ord-119599b68afe42bb8e9735c12c06a9dc
Quelldatensatz
uspto-grants-1991_06
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05023242

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