Hydrochloric Acid → 6-(Piperazin-1-yl)pyridine-3-carboxylic acid

HRID 1494268Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1494268
C(OC([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][N:13]=2)[CH2:8][CH2:7]1)=O)C.[OH-].[K+].Cl>O>[N:9]1([C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][N:13]=2)[CH2:8][CH2:7][NH:6][CH2:11][CH2:10]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 14987925HCID 14987925, Verbindung

Produkt 1

HCID 27717596-(Piperazin-1-yl)pyridine-3-carboxylic acidAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

2.8 g of 6-(4-ethoxycarbonyl-1-piperazinyl)nicotinic acid obtained in Example 1 and 2 g of potassium hydroxide were dissolved in 20 ml of water. The solution was heated under reflux for 2 hours. After cooled, the reaction mixture was neutralized with concentrated hydrochloric acid and crystals precipitated were filtered, washed with water and dried to give 1.7 g of 6-(1-piperazinyl)nicotinic acid (yield 82%).

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 2 hours
  3. temperatureAfter cooled
  4. customprecipitated
  5. filtrationwere filtered
  6. washwashed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-026e311ef5414df690d7f73bbcd7519f
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05025012

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