Ammonia → 7-Bromoquinolin-5-ol

HRID 1496844Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1496844
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[C:4]([O:12]C)[CH:3]=1.Br.N>O>[OH:12][C:4]1[CH:3]=[C:2]([Br:1])[CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 260Hydrogen BromideHCID 712378127-Bromo-5-methoxyquinoline

Produkt 1

HCID 1362166197-Bromoquinolin-5-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1.5 g (0.0064 mol) of 7-bromo-5-methoxy-quinoline were refluxed with 48% HBr (30 ml) for 20h. After cooling to room temperature reaction mixture was poured into 100 ml of water and basified with saturated ammonia solution. Product was filtered off, washed with water and dried at 50° C. in vacuo. Yield of 7-bromo-5-hydroxy-quinoline was 600 mg (41%).

Aufarbeitung

  1. customreaction mixture
  2. filtrationProduct was filtered off
  3. washwashed with water
  4. customdried at 50° C. in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-02bdefb191324228bee808c9a6938667
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09199937B2

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