Potassium Carbonate → 1-(4-(3-Ethoxy-4-nitrophenyl)piperazin-1-yl)ethanone

HRID 1496945

Reaktionsgleichung

Reaktionsgleichung von HRID 1496945
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH2:12][CH3:13])[CH:3]=1.[C:14]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)(=[O:16])[CH3:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:12]([O:11][C:4]1[CH:3]=[C:2]([N:20]2[CH2:21][CH2:22][N:17]([C:14](=[O:16])[CH3:15])[CH2:18][CH2:19]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9])[CH3:13]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 837951-AcetylpiperazineHCID 129181532-Ethoxy-4-fluoronitrobenzene

Produkt 1

HCID 1181057541-(4-(3-Ethoxy-4-nitrophenyl)piperazin-1-yl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The compound obtained in Step 1 above (300 mg), N-acetylpiperazine (300 mg), and potassium carbonate (500 mg) were dissolved in dimethylformamide (3 mL) and reacted at 80° C. overnight. The dimethylformamide of the reaction mixture was removed under reduced pressure, and added with water to form a solid. The solid was filtered to obtain a target compound as a yellow solid.

Aufarbeitung

  1. customreacted at 80° C. overnight
  2. customThe dimethylformamide of the reaction mixture was removed under reduced pressure
  3. additionadded with water
  4. customto form a solid
  5. filtrationThe solid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-2c8e1a83285440b6b1edfc06111e3ca8
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09199944B2

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