Diphosgene → (3R)-1-azabicyclo[2.2.2]octan-3-yl carbonochloridate hydrochloride
Reaktionsgleichung
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([OH:9])[CH2:2]2.[Cl:10][C:11](OC(Cl)(Cl)Cl)=[O:12]>C(#N)C>[ClH:10].[C:11]([Cl:10])(=[O:12])[O:9][C@@H:3]1[CH:4]2[CH2:7][CH2:8][N:1]([CH2:6][CH2:5]2)[CH2:2]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
To a stirred solution of (R)-3-quinuclidinol (2.5 g, 19.66 mmol) in acetonitrile (200 mL) was added trichloromethyl chloroformate (3.06 mL, 25.57 mmol) dropwise at 0° C. and the mixture was allowed to stir at 0° C. for 1 hour. The reaction mixture was then stirred at RT for 16 hours and then the solvent was removed in vacuo to afford the title compound as a white solid (4.39 g, 98%).
Aufarbeitung
- stirringThe reaction mixture was then stirred at RT for 16 hours
- customthe solvent was removed in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-2258874935574077b07e9e07c69adbbf
- Quelldatensatz
- uspto-grants-2015_12
- Patentnummer
- US09199980B2
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