2,4-Dichloropyrimidine → 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

HRID 14983

Reaktionsgleichung

Reaktionsgleichung von HRID 14983
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[CH:15][CH:16]=1)=[O:10]>>[Cl:1][C:2]1[N:7]=[C:6]([C:15]2[CH:16]=[C:11]([CH:12]=[CH:13][CH:14]=2)[CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 775312,4-DichloropyrimidineHCID 27343563-Formylphenylboronic acid

Produkt 1

HCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehydeAusbeute 60 %

Versuchsvorschrift

2,4 dichloropyrimidine and 3-formyl phenyl boronic acid were coupled following procedure A. The yield was 60%. LC-MS showed the product was >95% pure and had the expected M+H+ of 219. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 10.1 (s, 1H) 8.7 (d, 1H) 8.6 (m, 1H) 8.4 (m, 1H) 8.1 (m, 1H) 7.7 (m, 2H).

Quellen und Nachweise

ORD-Eintrag
ord-865e1b4d39e34a55adfe40d5054d0d71
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732444B2

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