Maleic Acid → Sunitinib Malate

HRID 1500395

Reaktionsgleichung

Reaktionsgleichung von HRID 1500395
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]\[C:33]([OH:35])=[O:34]>CO.ClCCl>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[CH2:31]([C:30]([OH:37])=[O:36])[C@H:32]([OH:10])[C:33]([OH:35])=[O:34]

Komponenten

5

Edukt 2

HCID 444266Maleic AcidHCID 5329102Sunitinib

Produkt 1

HCID 6456015Sunitinib MalateAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
27.5 °C

Versuchsvorschrift

Sunitinib (2.0 g) was suspended in 10% methanol in dichloromethane at 25° C. , followed by addition of maleic acid (0.58 g) .The reaction mass was maintained under stirring at 25-30° C. for 60 minutes. The solids obtained were filtered, suck dried and dried under vacuum for a period of 10 hrs at 60° C. to obtain sunitinib maleate. (2.3 g; yield: 89%)

Aufarbeitung

  1. temperaturewas maintained
  2. customThe solids obtained
  3. filtrationwere filtered
  4. customsuck dried
  5. customdried under vacuum for a period of 10 hrs at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-8d00f1b7495c4220923c190eecedc582
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206163B2

Verknüpfte Notizen

Wird geladen…