Triphenylphosphine → HCID 86718007, Verbindung

HRID 1500469Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1500469
O[C@@H:2]([CH3:12])[CH2:3][C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=1[OH:11].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>C1COCC1>[CH3:12][C@@H:2]1[CH2:3][C:4]2[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=2[O:11]1

Komponenten

5

Edukt 3

HCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 86718006HCID 86718006, Verbindung

Produkt 1

HCID 86718007HCID 86718007, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a mixture of (S)-2-(2-hydroxypropyl)-4-methylphenol (3c) (1.6 g, 8.4 mmol) and triphenylphosphine (2.7 g, 10 mmol) in THF (60 mL) was added DIAD at ambient temperature. It was concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with hexanes/EtOAc (10:1) to give the title compound (3d).

Aufarbeitung

  1. concentrationIt was concentrated in vacuo
  2. customThe residue was purified by column chromatography on silica gel eluting with hexanes/EtOAc (10:1)

Quellen und Nachweise

ORD-Eintrag
ord-2e574ee400bf45f883d79ad70b89b075
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206166B2

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