HCID 86718008, Verbindung → HCID 86718009, Verbindung

HRID 1500471Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1500471
[CH3:1][C@@H:2]1[CH2:6][C:5]2[CH:7]=[C:8]([CH3:14])[CH:9]=[C:10]([N+:11]([O-])=O)[C:4]=2[O:3]1>C1COCC1.[Pd]>[CH3:1][C@@H:2]1[CH2:6][C:5]2[CH:7]=[C:8]([CH3:14])[CH:9]=[C:10]([NH2:11])[C:4]=2[O:3]1

Komponenten

4

Edukt 1

HCID 86718008HCID 86718008, Verbindung

Produkt 1

HCID 86718009HCID 86718009, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The mixture of (R)-2,5-dimethyl-7-nitro-2,3-dihydrobenzofuran (3e) (0.84 g, 4.3 mmol) and Pd/C (100 mg, 15%) in THF (10 mL) was introduced H2 at ambient temperature. It was stirred at ambient temperature for 12 h. The mixture was filtered through Celite and concentrated to give the title compound (3f) as a solid. MS-ESI (m/z): 164 (M+1)+.

Aufarbeitung

  1. additionwas introduced H2 at ambient temperature
  2. filtrationThe mixture was filtered through Celite
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a1152d0534f648f7977fa159ea8673db
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206166B2

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