Methanol → HCID 71115123, Verbindung

HRID 1502391Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1502391
Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=2[CH3:19])[CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([NH:20][C:21]([CH:23]1[CH2:25][CH2:24]1)=[O:22])[N:6]=[CH:7]2.F[B-](F)(F)F.F[B-](F)(F)F.C1(P(C2CCCCC2)CCCP(C2CCCCC2)C2CCCCC2)CCCCC1.[C:65](=[O:68])([O-])[O-:66].[K+].[K+].[CH3:71]O>C(OCC)(=O)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.CN(C)C=O>[CH:23]1([C:21]([NH:20][C:5]2[CH:4]=[C:3]3[C:8]([CH:9]=[C:10]([C:12]4[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=4[CH3:19])[N:11]=[C:2]3[C:65]([O:66][CH3:71])=[O:68])=[CH:7][N:6]=2)=[O:22])[CH2:25][CH2:24]1

Komponenten

8

Edukt 4

HCID 887MethanolHCID 11430Potassium CarbonateHCID 57410130HCID 57410130, VerbindungHCID 71317487Phosphine, 1,1'-(1,3-propanediyl)bis[1,1-dicyclohexyl-, tetrafluoroborate(1-) (1:2)

Produkt 1

HCID 71115123HCID 71115123, VerbindungAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 167845palladium(II) acetateKatalysatorHCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of N-(5-chloro-7-(5-fluoro-2-methylphenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide (50 mg, 0.14 mmol), palladium acetate (2 mg, 0.007 mmol), 1,3-bis(dicyclohexylphosphino)propane bis(tetrafluoroborate) (9 mg, 0.014 mmol), potassium carbonate (29 mg, 0.21 mmol), methanol (0.1 mL), and N,N-dimethylformamide (1 mL) was purged with nitrogen and evacuated (3×), flushed with carbon monoxide and evacuated (2×), and then left under a carbon monoxide balloon and heated at 100° C. for 2 hours. The cooled reaction mixture was diluted with ethyl acetate (50 mL) and washed with water (100 mL). The organic layer was separated, dried over sodium sulfate, filtered, and evaporated in vacuo to afford a residue that was purified by flash chromatography (silica, 4 g, ISCO, 0-50% ethyl acetate in heptane) to afford the title compound as a pale yellow solid (50 mg, 90%), which was used in the next step without further purification.

Aufarbeitung

  1. customwas purged with nitrogen
  2. customevacuated (3×)
  3. customflushed with carbon monoxide
  4. customevacuated (2×)
  5. waitleft under a carbon monoxide balloon
  6. customThe cooled reaction mixture
  7. washwashed with water (100 mL)
  8. customThe organic layer was separated
  9. dry with materialdried over sodium sulfate
  10. filtrationfiltered
  11. customevaporated in vacuo
  12. customto afford a residue that
  13. customwas purified by flash chromatography (silica, 4 g, ISCO, 0-50% ethyl acetate in heptane)

Quellen und Nachweise

ORD-Eintrag
ord-b0b6c3ecf7114c93bee005fe16d146b7
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206175B2

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