Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

HRID 15035

Reaktionsgleichung

Reaktionsgleichung von HRID 15035
C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][N:29]([C:32]2[CH:37]=[CH:36][C:35]([O:38]C3CCCCO3)=[CH:34][CH:33]=2)[C:28](=[O:45])[CH:27]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][N:29]([C:32]2[CH:33]=[CH:34][C:35]([OH:38])=[CH:36][CH:37]=2)[C:28](=[O:45])[CH:27]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

4

Edukt 2

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 684306714-benzyloxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one

Produkt 1

HCID 684312834-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-oneAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Pyridinium p-toluenesulfonate (65 mg) was added to an ethanol solution (16 mL) of 4-benzyloxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one (982 mg, 2.60 mmols) and refluxed for an hour. The reaction liquid was cooled to room temperature and the precipitate was recovered by filtration and washed with water and ethyl acetate to provide the title compound (746 mg, 98%).

Aufarbeitung

  1. temperaturerefluxed for an hour
  2. customThe reaction liquid
  3. filtrationthe precipitate was recovered by filtration
  4. washwashed with water and ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-7d8e8bb1d0ff40a88da8478839fb9b50
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732456B2

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