Hydrogen Bromide → Adipic Acid

Temperatur

160 °C

20 mg catalyst (1.7% Pt-0.6% Rh/Davisil 635) was dispensed into a 1.2 mL vial. Glacial acetic acid was added followed by a 10% water/acetic acid solution according to Table 1. 50 μL of an acetic acid solution containing 1.2 M HBr and 1.6 M D-glucaric acid was added bringing the final solution volume to 100 μL. The vials were transferred to a pressure reactor which was then sealed, purged with nitrogen and pressurized with hydrogen to 820 psig at room temperature. The reactor was agitated and heated to 160° C. for 90 minutes. After 90 minutes, the reactor was cooled to room temperature, vented, and purged with nitrogen prior to being unsealed. Adipic acid yields were determined by mass spectrometry relative to a d8-adipic acid internal standard.

1. additionwas added
2. customThe vials were transferred to a pressure reactor
3. customwhich was then sealed
4. custompurged with nitrogen
5. custompressurized with hydrogen to 820 psig at room temperature
6. temperaturethe reactor was cooled to room temperature
7. custompurged with nitrogen

ORD-Eintrag

ord-5f27538135994f82a4a4294cb4d5b1f8

Quelldatensatz

uspto-grants-2015_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09216937B2