Chloroform → 3-(2-Bromoethyl)phenol

HRID 1505148Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1505148
[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10]C)[CH:5]=1.C(Cl)(Cl)Cl.B(Br)(Br)Br.[NH4+].[OH-]>C(Cl)Cl>[Br:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1

Komponenten

6

Edukt 4

HCID 6212ChloroformHCID 14923Ammonium HydroxideHCID 25134Boron tribromideHCID 1374501-Bromo-2-(3-methoxyphenyl)ethane

Produkt 1

HCID 5723003-(2-Bromoethyl)phenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

A solution of 1-(2-bromoethyl)-3-methoxybenzene (1.00 g, 4.7 mmol) in CHCl3 (50 mL, 0.6 mol) was cooled to at 0° C. 1.0 M of BBr3 in DCM (27.9 mL) was cooled to 0° C. and added to the solution. The solution was allowed to warm to 30° C. over 30 minutes, then was poured into a solution of ice and 30% NH4OH, which was stirred at 0° C. for 30 minutes. The organic layer was taken and concentrated with no reduced pressure.

Aufarbeitung

  1. additionadded to the solution
  2. concentrationconcentrated with no reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a8bae890a3284814aabc2a6c29d38fe6
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09216971B2

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