HCID 67235239, Verbindung → HCID 67235719, Verbindung

HRID 1505324Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1505324
[CH3:1][CH:2]([O:4][C:5]1[CH:6]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][N:13]=2)[CH:8]=[CH:9][CH:10]=1)[CH3:3]>CO.[Pd]>[CH3:3][CH:2]([O:4][C:5]1[CH:6]=[C:7]([O:11][C:12]2[N:13]=[CH:14][C:15]([NH2:18])=[CH:16][CH:17]=2)[CH:8]=[CH:9][CH:10]=1)[CH3:1]

Komponenten

4

Edukt 1

HCID 67235239HCID 67235239, Verbindung2×

Produkt 1

HCID 67235719HCID 67235719, VerbindungAusbeute 93,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-({3-[(1-methylethyl)oxy]phenyl}oxy)-5-nitropyridine (Intermediate 28, 670 mg, 2.45 mmol) in methanol (50 mL) was added Pd/C (10%, 100 mg, 0.1 wet. e.g.) and the flask was filled in with H2. The resulting mixture was stirred at room temperature under H2 atmosphere overnight and filtered. The filtrate was concentrated under vacuum to afford the title compound as a brown solid (560 mg).

Aufarbeitung

  1. additionthe flask was filled in with H2
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-9fab902458bc4fceb25c2ef4fc03254a
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09216967B2

Notizen zur Reaktion

Wird geladen…