HCID 131734349, Verbindung → HCID 68322480, Verbindung
Reaktionsgleichung
CC([N:5]([C@@H:9]([C:12]([NH:14][C:15]1[CH:16]=[N:17][C:18]([O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[C:24]([C:30]([CH3:32])=[CH2:31])[CH:23]=2)=[CH:19][CH:20]=1)=[O:13])[CH2:10][CH3:11])[C:6](=[O:8])[O-:7])(C)C>CO.[Pd]>[C:28]([C:25]1[CH:26]=[CH:27][C:22]([O:21][C:18]2[N:17]=[CH:16][C:15]([NH:14][C:12]([C@H:9]([NH:5][C:6](=[O:8])[O:7][C:24]([CH3:30])([CH3:25])[CH3:23])[CH2:10][CH3:11])=[O:13])=[CH:20][CH:19]=2)=[CH:23][C:24]=1[CH:30]([CH3:31])[CH3:32])#[N:29]Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of 1,1-dimethylethyl((1R)-1-{[(6-{[4-cyano-3-(1-methylethenyl)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate (Intermediate 178, 73 mg) in MeOH (10 mL) was added Pd 10% w/w on activated carbon (14 mg) and the reaction mixture was stirred for 30 minutes under H2 atmosphere (P=1 atm). The catalyst was filtered off and the solvent removed under reduced pressure. The residue was purified by flash chromatography on silica gel (SNAP 10 g) eluting from 75:25 to 40:60 cyclohexane/ethyl acetate affording the title compound (62 mg) as white solid.