Urea → 6-METHOXYQUINAZOLINE-2,4-DIOL

HRID 1507415Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1507415
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:13][C:14](N)=[O:15]>O>[CH3:12][O:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[NH:1][C:14](=[O:15])[NH:13][C:4]2=[O:6]

Komponenten

4

Edukt 2

HCID 1176UreaHCID 2779305-Methoxyanthranilic acid

Produkt 1

HCID 103302006-METHOXYQUINAZOLINE-2,4-DIOLAusbeute 88,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

A mixture of 2-amino-5-methoxybenzoic acid (5.00 g, 29.9 mmol) and urea (5.40 g, 90.0 mmol) was heated to 200° C. for 1 hour. The mixture was cooled to room temperature and diluted with H2O (50 mL), the mixture was filtered off and the precipitate was washed with H2O (10 mL), dried in vacuo to give the product (5.10 g, yield 88%).

Aufarbeitung

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe mixture was filtered off
  3. washthe precipitate was washed with H2O (10 mL)
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d00d3ed83552499a862b7da9ee825b13
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09221810B2

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