Sodium Methoxide → HCID 86069111, Verbindung

HRID 1508244Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1508244
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[C:10](Br)=[CH:9][CH:8]=[N:7][C:6]=1[Cl:12])[CH3:2].[CH3:14][O-:15].[Na+]>CO.CCOC(C)=O>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[C:10]([O:15][CH3:14])=[CH:9][CH:8]=[N:7][C:6]=1[Cl:12])[CH3:2]

Komponenten

5

Edukt 2

HCID 10942334Sodium MethoxideHCID 84819634Ethyl 4-bromo-2-chloronicotinate

Produkt 1

HCID 86069111HCID 86069111, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a solution of 4-bromo-2-chloronicotinic acid ethyl ester (5.06 mmol) in 15 mL MeOH was added 1.0 mL of a solution of NaOMe (30% in MeOH). The reaction mixture was stirred at 40° C. for 4 h, cooled to RT, diluted with EtOAc and then quenched with sat. aq. NH4Cl solution. The organic layers was dried over MgSO4 and concentrated in vacuo to give the desired compound as brown oil;

Aufarbeitung

  1. temperaturecooled to RT
  2. customquenched with sat. aq. NH4Cl solution
  3. dry with materialThe organic layers was dried over MgSO4
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f11930c306814e92a4e8cfe1c8246883
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09221832B2

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