Diethyl Oxalate → Ethyl 2-oxo-3-phenylpropanoate

HRID 1508423Notizen

Reaktionsgleichung

F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11].C(Br)C1C=CC=CC=1.[Mg].C(OCC)(=O)C(OCC)=O>>[C:3]1([CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

Komponenten

Edukt 4

HCID 7268Diethyl Oxalate

HCID 7498Benzyl Bromide

HCID 5462224Magnesium

HCID 18370709Ethyl (2-fluorophenyl)pyruvate

Produkt 1

HCID 12292599Ethyl 2-oxo-3-phenylpropanoateAusbeute 80 %

Versuchsvorschrift

The title compound was prepared as described for B4 using benzyl bromide (1.250 g, 7.31 mmol), magnesium (0.195 g, 8.04 mmol) and diethyl oxalate (2.136 g, 14.62 mmol) in the form of colorless oil in 80% yield and used instantly in next step.

Quellen und Nachweise

ORD-Eintrag: ord-52eb95a6d9b74cc5876a983ee0b66d2d
Quelldatensatz: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09221860B2

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