5-Ethyl-2-phenyl-oxazole-4-carboxylic acid benzyl ester → 2-Phenyl-5-ethyl-oxazole-4-carboxylic acid

HRID 1510280Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1510280
C([O:8][C:9]([C:11]1[N:12]=[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:14][C:15]=1[CH2:16][CH3:17])=[O:10])C1C=CC=CC=1>C(O)C.[Pd]>[CH2:16]([C:15]1[O:14][C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:12][C:11]=1[C:9]([OH:10])=[O:8])[CH3:17]

Komponenten

4

Edukt 1

HCID 674272275-Ethyl-2-phenyl-oxazole-4-carboxylic acid benzyl ester

Produkt 1

HCID 150939472-Phenyl-5-ethyl-oxazole-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 5-ethyl-2-phenyl-oxazole-4-carboxylic acid benzyl ester (1 g, 3.25 mmol) in 30 mL of ethanol was hydrogenated at 30 psi with 10% Pd/C (200 mg) at room temperature for two hours. The reaction mixture was filtered through a celite plug, evaporated and placed under high vacuum to give 5-ethyl-2-phenyl-oxazole-4-carboxylic acid, that was used without further purification. LCMS calcd for C12H11NO3 (m/e) 217, obsd 218 (M+H).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through a celite plug
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-78b5be3a815642dd9c05dad4911a088e
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08211914B2

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