Piperidine-1-propanol → 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-{3-hydroxy-prop-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

HRID 15108

Reaktionsgleichung

Reaktionsgleichung von HRID 15108
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]([CH3:25])([CH3:24])[C:11]([NH:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=O)=[C:16]([CH3:23])[CH:15]=2)=[O:12])=[O:8])=[CH:4][CH:3]=1.CCN(C(C)C)C(C)C.CN(C(ON1N=[N:50][C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][C:44]1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[OH:57][CH2:58][CH2:59]CN1CCCCC1>CN(C=O)C>[CH3:25][C:10]([NH:9][C:7]([C:5]1[S:6][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:8])([C:11](=[O:12])[NH:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]([N:50]2[CH2:45][CH2:46][CH2:47][CH2:48][CH:49]2[CH2:44][CH2:59][CH2:58][OH:57])=[O:20])=[C:16]([CH3:23])[CH:15]=1)[CH3:24]

Komponenten

6

Edukt 4

HCID 66032Piperidine-1-propanolHCID 81531Diisopropylethylamine2×HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 686377704-{2-[(5-Chloro-thiophene-2-carbonyl)-amino]-2-methyl-propionylamino}-2-methyl-benzoic acid

Produkt 1

HCID 587743615-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-{3-hydroxy-prop-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

200 μl of a 0.05 molar solution of 4-{2-[(5-chloro-thiophene-2-carbonyl)-amino]-2-methyl-propionylamino}-2-methyl-benzoic acid, which additionally contains 0.05 mol/l DIPEA, in DMF are combined with 100 μl of a 0.1-molar solution of TBTU in DMF on a microtitre plate and mixed for 10 mins on a shaker. Then 200 μl of a 0,05-molar solution of (3-hydroxy-prop-1-yl)-piperidine, which additionally contains 0.05 mol/l DIPEA, are pipetted in and again mixed in by shaking. After 16 h at ambient temperature the mixture is filtered through basic aluminium oxide and washed with DMF/methanol=9:1. Then it is evaporated down i. vac.

Aufarbeitung

  1. additionmixed for 10 mins on a shaker
  2. additionagain mixed in
  3. filtrationAfter 16 h at ambient temperature the mixture is filtered through basic aluminium oxide
  4. washwashed with DMF/methanol=9:1
  5. customThen it is evaporated down i

Quellen und Nachweise

ORD-Eintrag
ord-1df2cfb453494b1a936f45aad2419613
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732466B2

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