Lithium Hydroxide → 2-Ethylpyridin-3-ol
Reaktionsgleichung
C([O:4][C:5]1[C:6]([CH2:11][CH3:12])=[N:7][CH:8]=[CH:9][CH:10]=1)(=O)C.[Li+].[OH-]>C(O)C>[CH2:11]([C:6]1[C:5]([OH:4])=[CH:10][CH:9]=[CH:8][N:7]=1)[CH3:12]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 2-ethylpyridin-3-yl acetate (5.1 g, 31 mmol) in ethanol (50 mL) was added 3M LiOH (50 mL, 150 mmol). The reaction mixture stirred at ambient temperature for 30 minutes. The mixture was concentrated to dryness and purified over silica gel (10% MeOH in CH2Cl2) to afford 2-ethylpyridin-3-ol (2.5 g, 20 mmol).
Aufarbeitung
- concentrationThe mixture was concentrated to dryness
- custompurified over silica gel (10% MeOH in CH2Cl2)
Quellen und Nachweise
- ORD-Eintrag
- ord-8bfd3a82531f4e92b93367656bc76af4
- Quelldatensatz
- uspto-grants-2012_07
- Patentnummer
- US08212045B2
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