Isopropylamine → Isopropylpent-4-enylamine
Reaktionsgleichung
Br[CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6].[CH:7]([NH2:10])([CH3:9])[CH3:8]>>[CH:7]([NH:10][CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6])([CH3:9])[CH3:8]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
5-Bromo-1-pentene (42.3 mmol) was added to isopropylamine (423 mmol), and the mixture was stirred at 60° C. for 48 h in the dark in a sealed tube. Then the volatiles were evaporated at reduced pressure and the crude residue was dissolved in 50 mL of diethyl ether and washed twice with water. The organic phase was dried over Na2SO4. Evaporation of the solvent gave N-isopropylpent-4-en-1-amine as brownish oil (40%) which was used without any further purification.
Aufarbeitung
- customThen the volatiles were evaporated at reduced pressure
- dissolutionthe crude residue was dissolved in 50 mL of diethyl ether
- washwashed twice with water
- dry with materialThe organic phase was dried over Na2SO4
- customEvaporation of the solvent
Quellen und Nachweise
- ORD-Eintrag
- ord-10bb1bb12c72442182f0e9424001ecec
- Quelldatensatz
- uspto-grants-2012_07
- Patentnummer
- US08216999B2
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