2-(hydroxymethyl)-1H-indole-5-carbonitrile → 2-formyl-1H-indole-5-carbonitrile
Reaktionsgleichung
[OH:1][CH2:2][C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]#[N:13])=[CH:7][CH:6]=2>ClCCl.O=[Mn]=O>[CH:2]([C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]#[N:13])=[CH:7][CH:6]=2)=[O:1]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
MnO2 (1.76 g) was added to a solution of 2-(hydroxymethyl)-1H-indole-5-carbonitrile (D24) (290 mg) in dichloromethane (100 mL) at RT. The reaction mixture was stirred at RT for 1 hour. The solid was filtered off and washed with dichloromethane. The filtrate was concentrated to afford 2-formyl-1H-indole-5-carbonitrile (D28) (230 mg) as a white solid. MS (ES): C10H6N2O requires 170; found 169.1 (M−H+).
Aufarbeitung
- filtrationThe solid was filtered off
- washwashed with dichloromethane
- concentrationThe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-3ba200123d094626990593699608c7bf
- Quelldatensatz
- uspto-grants-2012_07
- Patentnummer
- US08217028B2
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