Water → 2-(Chloromethyl)-3,4-difluoro-1-methoxybenzene

HRID 1512967Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1512967
[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH2:4]O.S(Cl)([Cl:15])=O.O>C1(C)C=CC=CC=1>[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([O:11][CH3:12])[C:3]=1[CH2:4][Cl:15]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24386Thionyl ChlorideHCID 38708672,3-Difluoro-6-methoxybenzyl alcohol

Produkt 1

HCID 593096112-(Chloromethyl)-3,4-difluoro-1-methoxybenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 2,3-difluoro-6-methoxybenzyl alcohol (6.97 g) in toluene (100 mL) was added thionyl chloride (4.4 mL) in a dropwise manner at room temperature, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into water, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine twice, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the title compound (7.65 g).

Aufarbeitung

  1. extractionthe resulting mixture was extracted with ethyl acetate
  2. washThe extract was washed with water and brine twice
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c7ea50b9d7aa45b38bc8f6f1ea5d9a4e
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217069B2

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