2-Fluoroethanol → 2-Chloro-4-(2-fluoroethoxy)-5-(2,3-difluoro-6-methoxybenzyloxy)-1-nitrobenzene

To a solution of 5-chloro-2-(2,3-difluoro-6-methoxybenzyloxy)-4-nitrophenol (0.35 g), 2-fluoroethanol (71 mg) and triphenylphosphine (0.31 g) in tetrahydrofuran (1.5 mL) was added diisopropyl azodicarboxylate (40% toluene solution, 0.68 mL), and the mixture was stirred at room temperature for 1 hour. The reaction mixture was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=9/1−1/1) to give 2-chloro-4-(2-fluoroethoxy)-5-(2,3-difluoro-6-methoxybenzyloxy)-1-nitrobenzene (0.24 g). This material was dissolved in tetrahydrofuran (5 mL). To the solution were added methanol (3 mL) and nickel(II) bromide (7 mg). To the mixture was added sodium borohydride (70 mg) under ice-cooling, and the mixture was stirred at the same temperature for 30 minutes, and then stirred at room temperature for 30 minutes. The reaction mixture was poured into a saturated aqueous sodium hydrogen carbonate solution, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=3/1−1/1) to give the title compound (0.2 g).

1. customThe reaction mixture was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=9/1−1/1)

ORD-Eintrag

ord-e795faebe51145c580f383937d82f122

Quelldatensatz

uspto-grants-2012_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08217069B2