Formic Acid → N-(4-chlorophenyl)formamide

HRID 1514357

Reaktionsgleichung

Reaktionsgleichung von HRID 1514357
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH:9](O)=[O:10]>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH:9]=[O:10])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 78124-Chloroaniline

Produkt 1

HCID 17475N-(4-chlorophenyl)formamideAusbeute 88 %

Versuchsvorschrift

4-Chloroaniline (10 g, 78.4 mmol) and formic acid were heated to reflux for 30 minutes. The reaction mixture was concentrated in vacuo. Water was added and basified with sodium carbonate and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtrated and evaporated to give N-(4-chloro-phenyl)-formamide (10.7 g, 88%).

Aufarbeitung

  1. temperatureto reflux for 30 minutes
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. additionWater was added
  4. extractionextracted with ethyl acetate
  5. dry with materialThe combined organic phases were dried over magnesium sulphate
  6. filtrationfiltrated
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-2c1aabcd1275451db6168ebd9989e894
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08222262B2

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