1-[4-(Isobutylamino)-3-nitrophenyl]ethanone → 1-[3-Amino-4-(isobutylamino)phenyl]ethanone

HRID 1517182

Reaktionsgleichung

Reaktionsgleichung von HRID 1517182
[CH2:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:14])[CH3:13])=[CH:8][C:7]=1[N+:15]([O-])=O)[CH:2]([CH3:4])[CH3:3]>CO.[Pd]>[NH2:15][C:7]1[CH:8]=[C:9]([C:12](=[O:14])[CH3:13])[CH:10]=[CH:11][C:6]=1[NH:5][CH2:1][CH:2]([CH3:3])[CH3:4]

Komponenten

4

Edukt 1

HCID 595690481-[4-(Isobutylamino)-3-nitrophenyl]ethanone

Produkt 1

HCID 595690101-[3-Amino-4-(isobutylamino)phenyl]ethanoneAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 31.6 g (134 mM) of 1-[4-(isobutylamino)-3-nitrophenyl]-ethanone in 400 ml of methanol are added 3.2 g of 10% palladium-on-charcoal. The reaction medium is then placed under a hydrogen atmosphere at ambient pressure with vigorous stirring for 1 hour. The reaction medium is filtered through Celite and the solvent is evaporated off under vacuum to give 27.6 g of 1-[3-amino-4-(isobutylamino)phenyl]ethanone in quantitative yield, in the form of an oil.

Aufarbeitung

  1. filtrationThe reaction medium is filtered through Celite
  2. customthe solvent is evaporated off under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-5a2383039cfb4baaa21b514f761a8d28
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232272B2

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