Morpholine → 6-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-2-amine

HRID 1517460Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1517460
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH:16]=NC=N3)[C:10]=2[N:11]=1.N1C[CH2:22][O:21][CH2:20][CH2:19]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH2:16][CH2:22][O:21][CH2:20][CH2:19]3)[C:10]=2[N:11]=1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 576983146-Chloro-4-(1H-1,2,4-triazol-1-yl)pyrido[3,2-d]pyrimidin-2-amine

Produkt 1

HCID 576983306-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-2-amineAusbeute 244,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A suspension of 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-ylamine (0.1 g, 0.4 mmol) and morpholine (0.07 mL, 0.8 mmol) in DCM (10 mL) was stirred at room temperature for 48 hours. After the removal of solvent, the residue was purified by flash chromatography (using 5% i-PrOH/DCM as the eluent), providing the title compound (0.26 g, 99% yield) as a yellow solid which was characterised as follows: MS (m/z) 266.0 [M+H]+.

Aufarbeitung

  1. customAfter the removal of solvent
  2. customthe residue was purified by flash chromatography (

Quellen und Nachweise

ORD-Eintrag
ord-9192569dccb84dbf97a5d896373e223e
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232278B2

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