Acetanilide → 2-[4-tert-Butyl-5-methoxy-2-(2-oxo-1,2-dihydro-pyridin-3-yl)-benzyl]-isoindole-1,3-dione

HRID 1517527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1517527
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.N1C(=O)CC[C:13]1=O.C1(NS(C)(=O)=O)C=CC=CC=1.S1(=O)(=O)CCCCN1.[NH:38]1[CH2:43][CH2:42][CH2:41][CH2:40][C:39]1=[O:44].C[C:46]1([CH3:54])[CH2:51][C:50](=O)N[C:48](=[O:53])[CH2:47]1.C1(NC(C)=O)C=CC=CC=1.[CH2:65]([C:67]1([CH2:75]C)[C:72](=O)C=CN[C:68]1=O)C>>[C:67]([C:75]1[C:48]([O:53][CH3:13])=[CH:47][C:46]([CH2:54][N:5]2[C:1](=[O:11])[C:2]3[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4]2=[O:6])=[C:51]([C:40]2[C:39](=[O:44])[NH:38][CH:43]=[CH:42][CH:41]=2)[CH:50]=1)([CH3:72])([CH3:68])[CH3:65]

Komponenten

9

Edukt 8

HCID 904AcetanilideHCID 4994PyrithyldioneHCID 6809PhthalimideHCID 11439SuccinimideHCID 126652-PiperidoneHCID 142924,4-Dimethylpiperidine-2,6-dioneHCID 70970Methanesulfonamide, N-phenyl-HCID 3035081,4-Butanesultam

Produkt 1

HCID 461956232-[4-tert-Butyl-5-methoxy-2-(2-oxo-1,2-dihydro-pyridin-3-yl)-benzyl]-isoindole-1,3-dione

Versuchsvorschrift

The following are prepared analogously by displacement of A-3b with the anion derived from deprotonation of the amide or sulfonamide in parentheses: I-29 (pyrrolidine-2,5-dione), I-34 (N-phenyl-methanesulfonamide), I-16 ([1,2]thiazinane 1,1-dioxide), I-23 (piperidin-2-one), I-88 (4,4-dimethyl-piperidine-2,6-dione), I-89 (PhNHAc) and I-39 (3,3-diethyl-1H-pyridine-2,4-dione).

Aufarbeitung

  1. customThe following are prepared analogously by displacement of A-3b with the anion

Quellen und Nachweise

ORD-Eintrag
ord-76c1d80598934b5d85cc49c984816200
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232271B2

Notizen zur Reaktion

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