HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Phenylpiperazine → 3-(4-Methylpiperazin-1-yl)phenol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Phenylpiperazine | HCID 7096 | — |
| Edukt | 1-(3-Hydroxyphenyl)piperazine | HCID 2736597 | — |
| Edukt | methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-((4-phenylpiperazin-1-yl)methyl)thiazole-4-carboxylate | HCID 59447670 | — |
| Edukt | HCID 178499107 | HCID 178499107 | — |
| Produkt | 3-(4-Methylpiperazin-1-yl)phenol | HCID 11011455 | — |
Reaktionsschritte
Compound 87A was prepared in a similar manner to the synthesis of compound 62A by substituting compound 45C and phenylpiperazine with paraformahyde and 3-(piperazin-1-yl)phenol, respectively: 1H NMR (DMSO-d6): δ 9.07 (s, 1H), 6.94-6.98 (m, 1H), 6.36 (d, J=8.13, 2.4 Hz, 2H), 8.28-8.29 (m, 1H), 6.18-6.21 (m, 1H), 3.04-3.07 (m, 4H), 2.41-2.43 (m, 4H), 2.21 (s, 3H). ESI (+)/MS: 193 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08232273B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-1db435a09d5f493fa91f3a03b4cfc019 |
| Quellennotiz | uspto-grants-2012_07 |