4-Aminophenol → 4-(1-Methylpiperidin-4-ylamino)phenol

HRID 1518397

Reaktionsgleichung

Reaktionsgleichung von HRID 1518397
S1C2C=CC=CC=2N=C1N(COCC[Si](C)(C)C)C(C1C=CC=[C:17]2[C:22]=1[CH2:21][N:20]([C:23]1SC(CN3CCN(C4C=CC=CC=4)CC3)=C(C(OC)=O)N=1)[CH2:19][CH2:18]2)=O.C(C1SC(N2CCC3C(=C(C(=O)/N=C4/SC5C=CC=CC=5N/4COCC[Si](C)(C)C)C=CC=3)C2)=NC=1C(OC)=O)=O.[NH2:94][C:95]1[CH:100]=[CH:99][C:98]([OH:101])=[CH:97][CH:96]=1.CN1CCC(=O)CC1>>[CH3:23][N:20]1[CH2:21][CH2:22][CH:17]([NH:94][C:95]2[CH:100]=[CH:99][C:98]([OH:101])=[CH:97][CH:96]=2)[CH2:18][CH2:19]1

Komponenten

5

Edukt 4

HCID 4034-AminophenolHCID 740491-Methyl-4-piperidoneHCID 59447670methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-((4-phenylpiperazin-1-yl)methyl)thiazole-4-carboxylateHCID 178499107HCID 178499107, Verbindung

Produkt 1

HCID 437426714-(1-Methylpiperidin-4-ylamino)phenol

Versuchsvorschrift

The compound 104A was prepared in a similar manner to the synthesis of compound 62A by substituting 1-phenylpiperazine and compound 45C with 4-aminophenol and 1-methylpiperidin-4-one, respectively: ESI (+)/LC/MS: 207 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-162accf2cfdc405580c12bf184dc97fe
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232273B2

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