Potassium Carbonate → 6-Ethynylnaphthalen-2-ol

HRID 1518405

Reaktionsgleichung

Reaktionsgleichung von HRID 1518405
C[Si]([C:5]#[C:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([OH:17])[CH:11]=[CH:10]2)(C)C.C([O-])([O-])=O.[K+].[K+]>CO.C1COCC1.C(OCC)(=O)C>[C:6]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([OH:17])[CH:11]=[CH:10]2)#[CH:5]

Komponenten

6

Edukt 2

HCID 11430Potassium CarbonateHCID 594475526-((Trimethylsilyl)ethynyl)naphthalen-2-ol

Produkt 1

HCID 190817686-Ethynylnaphthalen-2-ol

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Compound 110A (770 mg, 3.20 mmol) in MeOH (5 ml) and THF (10 ml) was treated with K2CO3 (885 mg, 6.41 mmol) at room temperature for 3 h. The reaction was diluted with ethyl acetate and washed with water. The organic layer was concentrated and the residue was purified by flash chromatography, eluted with DCM to provide the compound 110B.

Aufarbeitung

  1. washwashed with water
  2. concentrationThe organic layer was concentrated
  3. customthe residue was purified by flash chromatography
  4. washeluted with DCM

Quellen und Nachweise

ORD-Eintrag
ord-b26daf207e0a4777895a4cc24c021b56
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232273B2

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