Dichloromethane → 2-(3,3-Difluoro-2-oxoindolin-1-yl)acetic acid

HRID 1519847Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1519847
[F:1][C:2]1([F:20])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[C:3]1=[O:19].C(Cl)Cl>C(O)=O>[F:20][C:2]1([F:1])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:11][C:12]([OH:14])=[O:13])[C:3]1=[O:19]

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 68754561tert-Butyl 2-(3,3-difluoro-2-oxoindolin-1-yl)acetate

Produkt 1

HCID 687551942-(3,3-Difluoro-2-oxoindolin-1-yl)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

A 30 mL reaction vial was charged with tert-butyl 2-(3,3-difluoro-2-oxoindolin-1-yl)acetate (275 mg, 1 mmol) as a yellow oil. DCM (3 mL) was added, followed by an equal volume of formic acid. The reaction was stirred for 16 h. The reaction mixture was concentrated under reduced pressure to give 2-(3,3-difluoro-2-oxoindolin-1-yl)acetic acid as a yellow solid. The desired M+H (228) was observed in the LCMS using the method [1] with a retention time of 1.652 min.

Aufarbeitung

  1. customA 30 mL reaction
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-dd22639bc42e46c08963effbada514bd
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09073891B2

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