Ammonium Chloride → HCID 10797271, Verbindung

HRID 1521748Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1521748
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH3:10])[C:5]([N+:11]([O-])=O)=[CH:4][CH:3]=1.[Cl-].[NH4+]>C(O)C.O.CCOC(C)=O.[Fe]>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH3:10])[C:5]([NH2:11])=[CH:4][CH:3]=1

Komponenten

7

Edukt 2

HCID 25517Ammonium ChlorideHCID 107267696-Chloro-N-ethyl-3-nitropyridin-2-amine

Produkt 1

HCID 10797271HCID 10797271, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 23925IronKatalysatorHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

To a solution of 6-chloro-N-ethyl-3-nitropyridin-2-amine (1.82 g, 9.04 mmol) in ethanol (20 mL) is added iron powder (2.52 g, 45.2 mmol) and a solution of ammonium chloride (2.42 g, 45.2 mmol) in H2O (8 mL). The mixture is heated in a microwave reactor at 140° C. for 30 min. The mixture is diluted with EtOAc, filtered and evaporated to afford the title compound as a brown oil (1.55 g, 100%) which was used in the next step without purification.

Aufarbeitung

  1. filtrationfiltered
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-1d5c5ed27ac343f0bc761c4559f73eb7
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09073926B2

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