Benzene → HCID 67124416, Verbindung

HRID 1522502

Reaktionsgleichung

Reaktionsgleichung von HRID 1522502
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][C:11](=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:5][CH:4]=1.C1C=CC=CC=1.[CH3:25][C:26]([N:29]1[C:33]([NH2:34])=[CH:32][C:31]([CH3:35])=[N:30]1)([CH3:28])[CH3:27]>C(O)(=O)C>[CH3:28][C:26]([N:29]1[C:33]2[N:34]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH:10]=[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:32]=2[C:31]([CH3:35])=[N:30]1)([CH3:25])[CH3:27]

Komponenten

5

Edukt 3

HCID 241BenzeneHCID 287267Ethyl 4-(4-methoxyphenyl)-2,4-dioxobutanoateHCID 7372001-tert-Butyl-3-methyl-1H-pyrazol-5-amine

Produkt 1

HCID 67124416HCID 67124416, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

The title compound was prepared in the same manner as described for intermediate 61 using ethyl 4-[4-(methyloxy)phenyl]-2,4-dioxobutanoate (327 mg, 1.305 mmol), benzene (8 mL), 1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-5-amine (200 mg, 1.305 mmol), and acetic acid (2 mL). The crude product was purified using column chromatography (Silica gel, eluent: 0 to 100% EtOAc/hexanes) to give 0.41 g (85%) of product. LCMS E-S (M+H)=368.1. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.81 (s, 9 H), 2.55 (s, 3 H), 7.11 (d, J=8.84 Hz, 2 H), 7.89 (s, 1 H), 8.16 (d, J=8.84 Hz, 2 H).

Aufarbeitung

  1. customThe crude product was purified

Quellen und Nachweise

ORD-Eintrag
ord-3b502d20205a47e39b96305c0309809a
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09073924B2

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