Methanol → 2-Chloro-4-hydrazinylpyrimidine

HRID 1523348Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1523348
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH2:9][NH2:10].CO.C(Cl)Cl>CCO>[Cl:1][C:2]1[N:7]=[C:6]([NH:9][NH2:10])[CH:5]=[CH:4][N:3]=1

Komponenten

6

Edukt 4

HCID 887MethanolHCID 6344DichloromethaneHCID 9321HydrazineHCID 775312,4-Dichloropyrimidine

Produkt 1

HCID 160921982-Chloro-4-hydrazinylpyrimidineAusbeute 94,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2,4-dichloropyrimidine (2.0 g) in EtOH (25 mL) was cooled to 0-20° C. and treated with hydrazine (2.8 mL). The progress of the reaction was followed by TLC using 10% MeOH:CH2Cl2 as mobile phase and visualizing under UV light. The mixture was concentrated under reduced pressure to afford 3.1 g of crude 2-chloro-4-hydrazinyl-pyrimidine (yield=94.8%).

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7c76fe8e93ea4d908152c62911b6ae1a
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09079865B2

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