Hydrazine hydrate (1:1) → HCID 86724908, Verbindung

HRID 1523717Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1523717
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15]C)=O)=[N:5]1)([CH3:3])[CH3:2].O.[NH2:18][NH2:19]>C(O)C>[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([NH:18][NH2:19])=[O:15])=[N:5]1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 10680335HCID 10680335, Verbindung

Produkt 1

HCID 86724908HCID 86724908, VerbindungAusbeute 6.715,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of methyl 1-isopropyl-1H-indazol-3-yl carboxylate (40.0 grams, 183.5 mmol, obtained in above step) in ethanol at room temperature hydrazine hydrate (130 mL, 2.56 mmol) was added. The reaction mixture was refluxed for 2 hours. The volatiles were removed under reduced pressure and the crude mass was diluted with dichloromethane, washed with water, brine, dried over anhydrous sodium sulphate and the solvent was removed under reduced pressure to obtain the title compound (37.52 grams).

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed for 2 hours
  2. customThe volatiles were removed under reduced pressure
  3. additionthe crude mass was diluted with dichloromethane
  4. washwashed with water, brine
  5. dry with materialdried over anhydrous sodium sulphate
  6. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4dfb8bb93adf48499c73af397eb0ecc4
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09079894B2

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