Diisopropylethylamine → tert-Butyl (1-((2-bromophenyl)sulfonyl)piperidin-4-yl)carbamate

HRID 1523762Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1523762
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](Cl)(=[O:10])=[O:9].[NH:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:14][CH2:13]1.C(N(C(C)C)CC)(C)C>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:12]1[CH2:13][CH2:14][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:22])[CH3:24])[CH2:16][CH2:17]1)(=[O:10])=[O:9]

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 5204032-Bromobenzenesulfonyl chlorideHCID 7238334-(N-Boc-amino)piperidine

Produkt 1

HCID 40175560tert-Butyl (1-((2-bromophenyl)sulfonyl)piperidin-4-yl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 2-bromobenzene-1-sulfonyl chloride (50 mg, 0.20 mmol), tert-butyl piperidin-4-ylcarbamate (49 mg, 0.25 mmol), and diisopropylethyl amine (0.101 mL, 0.59 mmol) in CH2Cl2 was stirred for 90 min at rt. The reaction mixture was then concentrated to dryness to give the title compound in quantitative yield. The product was used without further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-edf99ffd6d2d48e69cf4ddaa2ccdc846
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09079866B2

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