Sodium Chloride → t-Butyl 5-methylpyrazine-2-carboxylate

HRID 1524634

Reaktionsgleichung

Reaktionsgleichung von HRID 1524634
[CH3:1][C:2]1[CH:7]=[N:6][C:5]([C:8]([OH:10])=[O:9])=[CH:4][N:3]=1.ClC(Cl)(Cl)C(=N)O[C:15]([CH3:18])([CH3:17])[CH3:16].[Na+].[Cl-].CCOC(C)=O>C1COCC1>[CH3:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([O:10][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:9])=[N:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 5234Sodium ChlorideHCID 8857Ethyl AcetateHCID 1228315-Methyl-2-pyrazinecarboxylic acidHCID 2734700Tert-butyl 2,2,2-trichloroethanimidate

Produkt 1

HCID 57475683t-Butyl 5-methylpyrazine-2-carboxylateAusbeute 99,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A boron trifluoride-diethyl ether complex (91.7 μL) was added dropwise to a suspension of 2-methylpyrazine-5-carboxylic acid (1 g) and tert-butyl 2,2,2-trichloroacetimidate (4.75 g) in THF (20 mL) under ice-cooling. The reaction solution was warmed to RT, followed by stirring for 2 h. A saturated NaCl solution and EtOAc were added to the reaction solution, and the organic layer was separated. The organic layer was dried over anhydrous MgSO4, and the insoluble matter was separated by filtration. The filtrate was concentrated and purified by silica gel column chromatography to obtain the title compound (1.4 g). 1H-NMR (CDCl3) δ (ppm): 1.65 (s, 9H), 2.65 (s, 3H), 8.57 (d, J=1.2 Hz, 1H), 9.10 (d, J=1.6 Hz, 1H).

Aufarbeitung

  1. temperaturecooling
  2. customthe organic layer was separated
  3. dry with materialThe organic layer was dried over anhydrous MgSO4
  4. customthe insoluble matter was separated by filtration
  5. concentrationThe filtrate was concentrated
  6. custompurified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-05deb697799643f3b3d9c0332fc52531
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09079914B2

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