Ethanolamine → HCID 178472034, Verbindung

HRID 1525127Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1525127
[CH2:1]([O:3][C:4](=[O:21])[C:5](=[CH:17]OCC)[C:6](=[O:16])[C:7]1[C:8]([Cl:15])=[N:9][C:10]([Cl:14])=[C:11]([F:13])[CH:12]=1)[CH3:2].[CH2:22]([CH2:24][NH2:25])[OH:23]>CCOCC>[Cl:15][C:8]1[N:9]=[C:10]([Cl:14])[C:11]([F:13])=[CH:12][C:7]=1[C:6](/[C:5](=[CH:17]/[NH:25][CH2:24][CH2:22][OH:23])/[C:4]([O:3][CH2:1][CH3:2])=[O:21])=[O:16]

Komponenten

4

Edukt 2

HCID 700EthanolamineHCID 54342804Ethyl 2-(2,6-dichloro-5-fluoronicotinoyl)-3-ethoxyacrylate

Produkt 1

HCID 178472034HCID 178472034, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of 2,6-dichloro-α-(ethoxymethylene)-5-fluoro-β-oxo-3-pyridinepropanoic acid ethyl ester (1.00 g; prepared according to EP 132845) was treated with ethanolamine (0.18 mL). After a few minutes, the reaction mixture became sticky and was diluted with Hept/ether (1:1; 10 mL). After further stirring at rt for 1.5 h, the solvents were evaporated under reduced pressure and the crude yellow oil was directly used in the next step.

Aufarbeitung

  1. waitAfter a few minutes
  2. customthe solvents were evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6bca1d89d3284b12a828f59fd03bd676
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09079922B2

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