2-Methoxyethylamine → HCID 89510331, Verbindung

HRID 1525367Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1525367
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:45]2[CH:49]=[N:48][N:47]=[N:46]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[C:22](=[O:28])[NH:23][CH2:24][CH2:25][O:26][CH3:27])[CH:13]2[C:29]([NH:31][C:32]2[CH:44]=[CH:43][C:35]([C:36]([O:38]C(C)(C)C)=[O:37])=[CH:34][CH:33]=2)=[O:30])=[O:11])[CH:7]=1.COCCN.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.CCN(C(C)C)C(C)C>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:45]2[CH:49]=[N:48][N:47]=[N:46]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[C:22](=[O:28])[NH:23][CH2:24][CH2:25][O:26][CH3:27])[CH:13]2[C:29]([NH:31][C:32]2[CH:33]=[CH:34][C:35]([C:36]([OH:38])=[O:37])=[CH:43][CH:44]=2)=[O:30])=[O:11])[CH:7]=1

Komponenten

6

Edukt 4

HCID 80182-MethoxyethylamineHCID 81531DiisopropylethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 131733150HCID 131733150, Verbindung

Produkt 1

HCID 89510331HCID 89510331, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

(E)-tert-Butyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(2-methoxyethylcarbamoyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate: To 3A (46 mg, 0.073 mmol), 2-methoxyethanamine (5.49 mg, 0.073 mmol), BOP (32.3 mg, 0.073 mmol) in DMF (1 mL) was added DIEA (12.77 μL, 0.073 mmol). After 24 h, the reaction was quenched with H2O (10 mL) and extracted with EtOAc (3×20 mL). The combined organic layers were washed with brine (10 mL) and dried (MgSO4). MS (ESI) m/z: 686.0 (M+H)+.

Aufarbeitung

  1. customthe reaction was quenched with H2O (10 mL)
  2. extractionextracted with EtOAc (3×20 mL)
  3. washThe combined organic layers were washed with brine (10 mL)
  4. dry with materialdried (MgSO4)

Quellen und Nachweise

ORD-Eintrag
ord-0d107f98066d4dc0b52fb5381e438896
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09079929B2

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