[3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol → 3-Fluoro-2-(trifluoromethyl)pyridine-4-carbaldehyde

HRID 1527467Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1527467
[F:1][C:2]1[C:3]([C:10]([F:13])([F:12])[F:11])=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][OH:9]>C(Cl)Cl.O=[Mn]=O>[F:1][C:2]1[C:3]([C:10]([F:12])([F:13])[F:11])=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]=[O:9]

Komponenten

4

Edukt 1

HCID 68283421[3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol

Produkt 1

HCID 866738643-Fluoro-2-(trifluoromethyl)pyridine-4-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of (3-fluoro-2-trifluoromethyl-pyridin-4-yl)-methanol (0.620 g, 3.18 mmol) and activated MnO2 (3.20 g, 36.5 mmol) in CH2Cl2 was stirred at RT overnight. The solid was filtered off, washed with CH2Cl2, and the filtrate was concentrated under mildly reduced pressure to afford the title compound as a yellow liquid. MS (LC/MS): 212.0 [M+NH4]+, 226.0 [M+MeOH]+. tR (HPLC conditions c): 3.26 min.

Aufarbeitung

  1. filtrationThe solid was filtered off
  2. washwashed with CH2Cl2
  3. concentrationthe filtrate was concentrated under mildly reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8b86983cf75a440fb942803377df3f4b
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085555B2

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