Methyl morpholine oxide → 4-Formyl-2-phenylbenzoyl methionine methyl ester

HRID 1532832

Reaktionsgleichung

Reaktionsgleichung von HRID 1532832
[CH3:1][O:2][C:3](=[O:25])[C@H:4]([CH2:21][CH2:22][S:23][CH3:24])[NH:5][C:6](=[O:20])[C:7]1[CH:12]=[CH:11][C:10](Br)=[CH:9][C:8]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C[C:27]1(C)CC(C)OB(C=C)[O:28]1.C[N+]1([O-])CCOCC1>C1(C)C=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+].O.O1CCOCC1.O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Os](=O)(=O)(=O)=O>[CH3:1][O:2][C:3](=[O:25])[C@H:4]([CH2:21][CH2:22][S:23][CH3:24])[NH:5][C:6](=[O:20])[C:7]1[CH:12]=[CH:11][C:10]([CH:27]=[O:28])=[CH:9][C:8]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Komponenten

10

Edukt 3

HCID 82029Methyl morpholine oxideHCID 1073104,4,6-Trimethyl-2-vinyl-1,3,2-dioxaborinaneHCID 20622824(2-Phenyl4bromobenzoyl)-methionine methyl ester

Produkt 1

HCID 105712674-Formyl-2-phenylbenzoyl methionine methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 6

HCID 30318Osmium TetroxideKatalysatorHCID 178418397HCID 178418397, VerbindungKatalysatorHCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittelHCID 10340Sodium CarbonateLösungsmittelHCID 218864351,4-Dioxane--water (1/1)Lösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

A mixture of (2-phenyl-4-bromobenzoyl) methionine methyl ester (100 mmol), 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane (100 mmol), tetrakis(triphenylphosphine)palladium (0) (3 mmol) in toluene and 2 M sodium carbonate in water (100 mL) is heated at 80° C. until the starting methyl ester disappears. The resulting mixture is extracted with ether, and washed with water, brine, dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. The residue is then purified by column chromatography on silica gel. To a solution of the resulting vinyl compound in dioxane/water (4/1) is added osmium tetraoxide (0.03 equivalent), N-methylmorpholine N-oxide (3 equivalents), and the reaction is stirred at 25° C. until TLC analysis shows the reaction to be complete. The reaction mixture is extracted with ether, which is washed with water and brine, dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. The residue is then purified by column chromatography on silica gel to afford the title product.

Aufarbeitung

  1. extractionThe resulting mixture is extracted with ether
  2. washwashed with water, brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue is then purified by column chromatography on silica gel
  7. customthe reaction
  8. extractionThe reaction mixture is extracted with ether, which
  9. washis washed with water and brine
  10. dry with materialdried over anhydrous magnesium sulfate
  11. filtrationfiltered
  12. concentrationconcentrated in vacuo
  13. customThe residue is then purified by column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-64d87d992617438cbbffe0767df052a0
Quelldatensatz
uspto-grants-2001_03
Patentnummer
US06204293B1

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